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Thurman's mother, Nena Birgitte Caroline von Schlebrügge , was a fashion model who was born in Mexico City, Mexico, to German nobleman Friedrich Karl Johannes von Schlebrügge and Birgit Holmquist, who was from Trelleborg, Sweden. Birgit Holmquist, Thurman's grandmother, had stood model in 1930 for the statue of a nude woman that still stands overlooking the harbor of Smygehuk. Thurman's father, Robert Alexander Farrar Thurman, was born in New York City to Elizabeth Dean Farrar, a stage actress, and Beverly Reid Thurman, Jr., an Associated Press editor and U.N. translator. Thurman's mother was briefly married in 1964 to LSD guru Timothy Leary after the two were introduced by Salvador Dalí; she married Thurman's father in 1967.

Thurman's father, who would later become a recognized scholar and professor at Columbia University of Indo-Tibetan Buddhist studies, was the first westerner to be ordained as a Tibetan Buddhist monk. He gave his children a Buddhist upbringing: Uma is named after an Dbuma Chenpo (in Tibetan, "db" is silent; Mahamadhyamaka in Sanskrit, meaning "Great Middle Way"). She has three brothers, Ganden , Dechen and Mipam, and a half-sister named Taya from her father's previous marriage. She and her siblings spent extended amounts of time in Almora, India as children, and the Dalai Lama would sometimes visit their home.

Since Professor Thurman moved between various universities, the family often relocated when Uma was a child. She grew up mostly in Amherst, Massachusetts and Woodstock, New York. Thurman is described as having been an awkward and introverted young girl who was frequently teased as a child for her tall frame, unique angular bone structure, unusual name (sometimes using the name “Uma Karen” instead of her birth-name), and size 11 feet (Thurman's famously large feet would later be lovingly filmed by Quentin Tarantino in the films he made with her). Even friends made a point of highlighting her unusual features — when she was ten years old, a friend's mother suggested she receive a nose job.




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